Accurate prediction of binding between a major histocompatibility complex (MHC) allele and a peptide plays a major role in the synthesis of potential personalized cancer vaccines, reported a study published on July 13, 2020. The immune system struggles to distinguish between a cancerous and a healthy cell. In a patient suffering from cancer who has a particular MHC allele, only those peptides that bind with the MHC allele with high affinity, help the immune system recognize the cancerous cells.
These researchers used innovative modeling of 9251 possible MHC allele trigrams to identify about 258. These results significantly reduces the number of amino acid subsequences that need to be clinically tested when producing cancer vaccine candidates.