New Nano-Vaccine Shows Cancer Therapy Potential
Cancer immunotherapy has shown great potential in cancer therapy as, unlike traditional chemotherapy and radiation therapy, it aims to evoke the immune response instead of killing cells indiscriminately.
Cancer vaccines consisting of tumor-associated antigens (TAAs) can initiate a powerful anti-tumor immune response through antigen-presenting cells, such as dendritic cells (DCs) and macrophages, stated researchers in a new study published in the July 2021 edition of ScienceDirect.
And they have shown great potential in cancer prevention and therapy.
However, poor anticancer efficacy and an uncertain immunization process have previously limited the application of cancer vaccines.
A new multifunctional nano-vaccine comprising ovalbumin (OVA), MnO2, and polydopamine (OMPN) was prepared by a facile one-pot method.
The OMPN displayed excellent anticancer efficacy against an orthotopic melanoma and could also prevent liver metastasis in a tumor re-challenge mice model.
Additionally, the migration behavior of DCs in the inguinal lymph node after vaccination was tracked by MRI contrasted with OMPN, indicating successful DC activation and immune response.
The superior anticancer efficacy, especially the high efficiency against tumor metastasis, and the capability of tracking the immunization process make OMPN a very promising multifunctional nano-vaccine for cancer therapy, concluded these researchers.
The study's authors declared that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
This work was financially supported by the National Natural Science Foundation of China, the Zhejiang Provincial Natural Science Foundation of China, the Zhejiang University Education Foundation Global Partnership Fund. The China Postdoctoral Science Foundation, the National Postdoctoral Program for Innovative Talent, the Zhejiang Provincial Natural Science Foundation of China and the Zhejiang University.